Garcinia Cambogia is an evergreen tree in the St. John’s wort family. In South Asia, garcinia fruits have been used in cooking for centuries. The addition of garcinia is said to make food «more filling and satisfying». For centuries, this small gourd-like fruit has been made into a concentrated extract used in South India and Thailand as a salad dressing, fish preservative, and digestive aid. As a result of recent research, it has been found that one of the components contained in this plant — hydroxycitric acid (HCA) — can provide significant assistance to people suffering from overweight. In the fruits of Garcinia Cambogia, both the pulp and the peel are edible. However, GLA is found mainly in the peel. A standardized 50% hydroxycitric acid (Hydroxycitric acid [HCA]). This acid plays a critical role in weight loss. Hydroxycitric acid, as its name suggests, is similar in composition to citric acid. The presence of the latter, for example, in oranges and citrus fruits in general, is well known. Citric acid is common in nature, but GLA is found in a very small number of plants, and Garcinia Cambogia is one of them. The extract from the peel and fruit of Garcinia Cambogia has traditionally been used in folk medicine, in particular, in Indian Ayurveda. It was given for rheumatism, dropsy, delayed menstruation, for problems with the digestive system, as a means of activating its activity and a laxative, in the presence of worms and other parasites, for a benign tumor, and also for the treatment of dysentery. Cases of toxicity with regular use of garcinia as food or medicinal decoctions were not observed. This product has traditionally been consumed in large quantities by the inhabitants of the coast of South Asia for many centuries. The ability of Garcinia Cambogia to reduce weight has long attracted researchers. After the active active ingredient of the fruits of this plant, GLA, was established, intensive research began on this component. On the one hand, GLA can be seen as a new development in the field of drugs, the use of which promotes weight loss. On the other hand, its merits have been known to the scientific world for quite some time. The first articles on GLA were published by scientists at American universities in the 1970s. In addition, a number of well-known pharmaceutical companies have conducted experiments over the years to prove the effectiveness of this substance in solving the problem of overweight. Initially, intensive animal studies were carried out. The results of at least seven such studies, which included experiments on more than 100 experimental animals, are known. Experiments with the use of GLA have shown a significant reduction in weight in animals with a significant degree of obesity, caused genetically or by damage to the hypothalamus. In addition, studies have found a marked decrease in the synthesis of fatty acids and cholesterol in the liver after oral administration of GLA. The usual dose of the drug was 3 mg of GLA per kg of body weight. At this dosage, appetite was suppressed by 43% over 6.5 hours and by 29% over 24 hours. The food intake was compared during the specified time period. Importantly, there was no reactive effect (that is, a desire to eat more after the drug wore off). It turned out that the time of taking the drug is important. The greatest effect was observed when taking GLA 30-60 minutes before meals. Efficiency was also dependent on the dosage of the drug. Animal studies have also shown that GLA intake reduces fatty acid synthesis by about 40-70% within 8-12 hours following a meal. Human studies have shown that patients who took GLA lost an average of 5 kg in weight over 2 months. At the same time, there was a decrease in cravings for sweets, decreased appetite and increased energy. Cholesterol levels in individuals taking GLA were approximately 14% lower than in the control group taking placebo. That. garcinia cambogia provides a triple biochemical mechanism of physiological weight loss in the human body: 1. reduces the formation of fatty acids and cholesterol in the body, 2. enhances the oxidation of fat present in adipocytes. 3. regulates appetite. The biochemical mechanism of this process is as follows: hydroxycitric acid, having a similar structure to citric acid, which is formed in the cells of our body, inhibits the activity of the citrate lidase enzyme and thereby competitively inhibits the formation of acetyl-CoA, which, in turn, limits the further synthesis of fatty acids through malonyl-CoA. At the same time, under the action of GOC-citrine, the enzyme carnitine acyltransferase is activated, which activates the formation of carnitine and, accordingly, increases the transport of intracellular fatty acids in mitochondria and their oxidation in these subcellular formations. The regulatory effect of GOC-citrine on appetite lies in its indirect effect on the activity of hypothalamic neurons responsible for the feeling of hunger and satiety. By blocking the formation of fatty acids from carbohydrates, it maintains a glucose concentration at which hypothalamic neurons do not stimulate appetite.