Ginkgo Long in the treatment of initial manifestations of insufficiency of blood supply to the brain
One of the most popular herbal extracts in Europe for the correction of disorders of memory, thinking, cerebral circulation and peripheral circulation is an extract from the leaves of the ginkgo tree. (Ginkgo biloba-Egb). Ginkgo Long (Ginkgo Biloba) is an NSP herbal medicine available in tablet form. The composition of the 1st tablet: extract from the leaves of ginkgo (Ginkgo biloba) is standardized — 24% ginkgo flavone glycosides and 6% terpene lactones (3.1% ginkgolides A, B and C; 2.9% bilobalides). Purpose of the study: to continue studying the effectiveness of Ginkgo long (Ginkgo biloba) in the treatment of initial manifestations of insufficient blood supply to the brain. Our study included 25 patients (17 women, 8 men) aged 45-60 years (mean age 50.0 ± 1.0 years) with initial manifestations of insufficient blood supply to the brain. The diagnosis was established if the patient had signs of a general vascular disease (atherosclerosis, arterial hypertension) and complaints of headache, dizziness, tinnitus, memory impairment, decreased performance. The duration of the disease ranged from 1 to 9 years (average 4.2 ± 0.5 years). Labile arterial hypertension was noted in almost half of the patients — 12 (48%), coronary heart disease — in 3 (12%). 9 (36%) had concomitant somatic diseases: chronic pneumonia, duodenal ulcer, chronic cholecystitis, spastic colitis, chronic glomerulonephritis, urolithiasis. In the majority of observations — 15 (60%), the disease began with a headache. Less commonly, the first symptoms of the disease were dizziness — in 5 (20%) patients, memory loss — in 4 (16%), fatigue — in 3 (12%), noise in the head — in 1 (4%). Patients took 1 tablet 1 time per day with meals. The course of treatment was three months. The effectiveness of ginkgo long treatment was determined by the results of a clinical examination with a study of neurological status, blood pressure, heart rate, symptoms of the clinical syndrome (headache, dizziness, noise in the head, sleep disturbance, fatigue, memory impairment). Neurophysiological methods of efficiency control included electroencephalography with the analysis of the spectral power of the main rhythms. For statistical analysis of the research results, the Student’s method (t-test) was used. The main complaints of the patients were headache — in 25 (100%), fatigue — in 23 (92%), memory loss — in 21 (84%), sleep disturbance — in 20 (80%), dizziness — in 19 (76%) ), tinnitus — in 15 (60%). At the same time, 9 (36%) patients had all the listed symptoms of the disease, 17 (68%) patients had 5 out of 6 signs, in the remaining cases there were various combinations of 3-4 of these symptoms. In neurological symptoms in patients, instability in the Romberg position (85%), revival of tendon reflexes and periosteal reflexes (51%), and spontaneous horizontal nystagmus (37%) prevailed. The mean systolic blood pressure before treatment was 137.0 ± 3.0 mm Hg. Art., mean diastolic pressure — 85.0 ± 2.0 mm Hg. Art., the average heart rate — 75.0 ± 2.0 per minute. On the background EEG in the majority — 17 (68%) of the examined patients, the main alpha rhythm dominated. In 8 (32%) observations, a flattened EEG amplitude level was noted with an increase in the beta rhythm and a significant severity of low-amplitude slow-wave activity, mainly in the 6-band. Low-amplitude EEG as a whole occurred in 9 (36%) patients. Preservation of the activation reaction to light stimulation was noted in all patients, preservation of the rhythm mastery reaction in 17 (68%), weakening of this reaction in 8 (32%). Clinical observation revealed an improvement in the condition in all 25 (100%) patients. It was characterized by a significant decrease in the severity of the main clinical symptoms of the disease by the end of treatment. At the same time, the positive dynamics of the clinical syndrome of initial manifestations of insufficiency of blood supply to the brain was noted already by the 50th day of therapy. Thus, headache decreased in 67% of patients, fatigue and noise in the head — in 65%. This trend continued to the 90th day of taking Ginkgo Long (Ginkgo Biloba). Headache completely disappeared in 55%, noise in the head — in 51%, fatigue — in 39% of patients. The vast majority of patients stopped complaining about sleep disturbance (71%) and dizziness (69%). While taking the phytopreparation, one patient noted an increase in dizziness and one patient worsened sleep by the 30th day of treatment; these disorders did not require discontinuation of their treatment, since they quickly regressed on their own. Positive dynamics of neurological symptoms during the treatment period was noted in 57% of patients and in the vast majority of cases (79%) related to a decrease in instability in the Romberg position. At the end of the course of treatment, an increase in the EEG amplitude was noted in patients with their initially low level, as a result of which the amplitude level of the EEG returned to normal in the vast majority of patients — 21 (84%). After treatment with Ginkgo Long (Ginkgo Biloba), the reaction of assimilation of the rhythms of light stimuli also improved in the majority of patients in whom it was weakened. We also observed 10 patients after treatment for 6 months. The stability of positive changes in the clinical picture was noted. Therefore, a second course of treatment is recommended no earlier than six months later. Thus, our study showed good tolerability of the phytopreparation and its high efficiency in the treatment of initial manifestations of insufficiency of blood supply to the brain.